CREMA results: Foxj3

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Transcription factors associated with Foxj3_Tbl1xr1

Gene Symbol	Gene ID	Gene Info
Foxj3 Ensembl NCBI MGI UniProt	ENSMUSG00000032998.10	Foxj3
Tbl1xr1 Ensembl NCBI MGI UniProt	ENSMUSG00000027630.8	Tbl1xr1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

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CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Foxj3	chr4_119540226_119540466	176	0.834899	0.47	3.4e-04	Click!
Foxj3	chr4_119609673_119609824	11594	0.136222	-0.38	4.1e-03	Click!
Foxj3	chr4_119539709_119540211	181	0.720671	0.28	3.8e-02	Click!
Foxj3	chr4_119589443_119589736	31753	0.095205	-0.21	1.2e-01	Click!
Tbl1xr1	chr3_22190612_22190763	12505	0.228128	0.59	2.5e-06	Click!
Tbl1xr1	chr3_22076598_22077433	79	0.934548	0.53	3.5e-05	Click!
Tbl1xr1	chr3_22078324_22078475	1115	0.412083	0.22	1.1e-01	Click!
Tbl1xr1	chr3_22168545_22168696	19678	0.212677	0.10	4.7e-01	Click!
Tbl1xr1	chr3_22181127_22181278	21990	0.207054	-0.08	5.7e-01	Click!

Showing 1 to 9 of 9 entries

Activity of the Foxj3_Tbl1xr1 motif across conditions

Conditions sorted by the z-value of the Foxj3_Tbl1xr1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

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Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_112695608_112695943	96.63	Gm18883	predicted gene, 18883	3904	0.16
chr12_3236518_3237725	73.32	Rab10os	RAB10, member RAS oncogene family, opposite strand	510	0.74
chr9_124439906_124440949	50.20	Ppp2r3d	protein phosphatase 2 (formerly 2A), regulatory subunit B'', delta	441	0.79
chrY_90739614_90740540	48.57	Mid1-ps1	midline 1, pseudogene 1	12980	0.18
chr5_32713265_32714499	43.10	Gm43852	predicted gene 43852	106	0.94
chr14_14350947_14351733	39.46	Il3ra	interleukin 3 receptor, alpha chain	1719	0.23
chr11_112501711_112502406	33.85	BC006965	cDNA sequence BC006965	167340	0.04
chr17_52601056_52601789	33.69	Gm27217	predicted gene 27217	1238	0.39
chr9_45663652_45664379	32.37	Dscaml1	DS cell adhesion molecule like 1	8822	0.19
chr13_84059070_84059621	31.94	Gm17750	predicted gene, 17750	5427	0.24

Showing 1 to 10 of 200 entries

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxj3_Tbl1xr1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.7	268.6	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
4.2	202.6	GO:0051965	positive regulation of synapse assembly(GO:0051965)
1.2	134.1	GO:0007626	locomotory behavior(GO:0007626)
42.6	127.8	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
17.3	121.0	GO:0016198	axon choice point recognition(GO:0016198)
6.3	113.8	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
3.8	111.6	GO:0019228	neuronal action potential(GO:0019228)
8.2	106.8	GO:0021952	central nervous system projection neuron axonogenesis(GO:0021952)
3.1	99.8	GO:0007019	microtubule depolymerization(GO:0007019)
3.9	94.7	GO:0051966	regulation of synaptic transmission, glutamatergic(GO:0051966)

Showing 1 to 10 of 820 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.5	346.4	GO:0045211	postsynaptic membrane(GO:0045211)
5.2	238.0	GO:0042734	presynaptic membrane(GO:0042734)
3.4	188.4	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
4.3	170.1	GO:0043198	dendritic shaft(GO:0043198)
0.7	134.7	GO:0030424	axon(GO:0030424)
1.7	127.4	GO:0030426	growth cone(GO:0030426)
5.0	126.0	GO:0044295	axonal growth cone(GO:0044295)
6.8	115.7	GO:1902711	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
4.6	115.6	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
1.5	112.2	GO:0014069	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)

Showing 1 to 10 of 240 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.6	144.0	GO:0004890	GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917)
3.5	126.7	GO:0015459	potassium channel regulator activity(GO:0015459)
40.0	120.1	GO:0005519	cytoskeletal regulatory protein binding(GO:0005519)
3.7	97.3	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
4.7	93.0	GO:0017075	syntaxin-1 binding(GO:0017075)
17.9	89.5	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
3.5	86.5	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
3.6	82.9	GO:0045499	chemorepellent activity(GO:0045499)
6.9	82.6	GO:0005313	L-glutamate transmembrane transporter activity(GO:0005313)
24.9	74.6	GO:0097109	neuroligin family protein binding(GO:0097109)

Showing 1 to 10 of 383 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.9	158.3	PID NETRIN PATHWAY	Netrin-mediated signaling events
2.3	74.8	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
1.8	55.3	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
2.2	52.2	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.8	50.5	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
2.5	38.0	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.9	33.9	PID SHP2 PATHWAY	SHP2 signaling
1.5	32.4	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
1.7	32.3	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
1.8	32.1	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family

Showing 1 to 10 of 50 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.1	176.6	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
10.0	120.3	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
5.2	118.7	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
3.2	105.0	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
6.9	104.0	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
7.0	98.2	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
4.8	76.1	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1	Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
6.7	74.1	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
6.6	72.7	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
5.1	71.4	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)

Showing 1 to 10 of 113 entries

Results for Foxj3_Tbl1xr1

Z-value: 8.60

Motif logo

Transcription factors associated with Foxj3_Tbl1xr1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Foxj3_Tbl1xr1 motif across conditions

Conditions sorted by the z-value of the Foxj3_Tbl1xr1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxj3_Tbl1xr1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: