CREMA results: Hmx2

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Transcription factors associated with Hmx2

Gene Symbol	Gene ID	Gene Info
Hmx2 Ensembl NCBI MGI UniProt	ENSMUSG00000050100.7	Hmx2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

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CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Hmx2	chr7_131554331_131554482	345	0.827262	0.06	6.4e-01	Click!
Hmx2	chr7_131553923_131554191	4	0.967049	0.06	6.5e-01	Click!

Showing 1 to 2 of 2 entries

Activity of the Hmx2 motif across conditions

Conditions sorted by the z-value of the Hmx2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

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Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr18_45123336_45123706	7.92	Gm4839	predicted gene 4839	23605	0.15
chr2_179535243_179535569	5.96	Gm14300	predicted gene 14300	78161	0.1
chr1_42691969_42692512	5.87	Pantr1	POU domain, class 3, transcription factor 3 adjacent noncoding transcript 1	853	0.48
chr2_14535423_14535658	5.82	Gm13266	predicted gene 13266	22941	0.16
chr6_138419995_138420190	5.79	Lmo3	LIM domain only 3	1360	0.42
chrX_58445733_58445903	5.69	Gm14645	predicted gene 14645	17743	0.26
chr13_84565715_84565948	5.68	Gm26913	predicted gene, 26913	125110	0.06
chr4_120170416_120170874	5.62	Edn2	endothelin 2	9439	0.24
chr14_99734308_99734471	5.48	Gm22970	predicted gene, 22970	39419	0.16
chr6_8956056_8956243	5.36	Nxph1	neurexophilin 1	6473	0.33

Showing 1 to 10 of 200 entries

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hmx2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.2	6.7	GO:0048022	negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.7	6.0	GO:0021830	interneuron migration from the subpallium to the cortex(GO:0021830)
2.0	5.9	GO:0060166	olfactory pit development(GO:0060166)
0.4	5.0	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.2	4.4	GO:0086010	membrane depolarization during action potential(GO:0086010)
1.3	3.8	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.1	3.6	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.6	3.5	GO:0051694	pointed-end actin filament capping(GO:0051694)
0.4	3.3	GO:0021860	pyramidal neuron development(GO:0021860)
0.3	3.2	GO:0071625	vocalization behavior(GO:0071625)

Showing 1 to 10 of 591 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.1	GO:0045211	postsynaptic membrane(GO:0045211)
0.4	6.3	GO:0098984	neuron to neuron synapse(GO:0098984)
0.1	6.3	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.1	5.1	GO:0042734	presynaptic membrane(GO:0042734)
0.4	4.5	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.6	3.8	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.2	3.2	GO:1902710	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.3	3.0	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.3	2.8	GO:0005883	neurofilament(GO:0005883)
0.1	2.6	GO:0005865	striated muscle thin filament(GO:0005865)

Showing 1 to 10 of 143 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	6.9	GO:0071837	HMG box domain binding(GO:0071837)
2.2	6.5	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)
0.2	5.7	GO:0005272	sodium channel activity(GO:0005272)
1.8	5.4	GO:0005519	cytoskeletal regulatory protein binding(GO:0005519)
1.1	4.4	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
0.4	3.9	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.3	3.8	GO:0022841	potassium ion leak channel activity(GO:0022841)
0.3	3.4	GO:0050811	GABA receptor binding(GO:0050811)
0.3	3.2	GO:0005523	tropomyosin binding(GO:0005523)
0.2	3.0	GO:0042813	Wnt-activated receptor activity(GO:0042813)

Showing 1 to 10 of 271 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.3	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	3.9	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	2.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	2.1	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.1	2.1	PID EPHA FWDPATHWAY	EPHA forward signaling
0.1	2.0	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.1	1.6	ST G ALPHA I PATHWAY	G alpha i Pathway
0.0	1.6	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.1	1.3	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1	1.2	PID NETRIN PATHWAY	Netrin-mediated signaling events

Showing 1 to 10 of 42 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	5.3	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1	5.2	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.2	4.2	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.4	3.9	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.1	3.4	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
0.2	3.1	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2
0.2	2.6	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	2.4	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.2	2.3	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2	2.3	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling

Showing 1 to 10 of 75 entries

Results for Hmx2

Z-value: 1.55

Motif logo

Transcription factors associated with Hmx2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Hmx2 motif across conditions

Conditions sorted by the z-value of the Hmx2 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hmx2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: