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ENCODE: ATAC-seq of different tissues during embryonic development
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CREMA is a free online tool that recognizes most
important transcription factors that change the chromatin
state across different samples.
Results for Zbtb18
Z-value: 16.76
Motif logo
Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:
This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.
For each TF, only the top 5 correlated CREs are shown.
| CRE | Gene | Distance | Association probability | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|---|---|
| Zbtb18 | chr1_177449970_177450141 | 4234 | 0.176238 | -0.61 | 9.0e-07 | Click! |
| Zbtb18 | chr1_177448201_177448585 | 2572 | 0.222652 | -0.59 | 1.7e-06 | Click! |
| Zbtb18 | chr1_177444261_177444423 | 47 | 0.950999 | -0.58 | 3.7e-06 | Click! |
| Zbtb18 | chr1_177447914_177448167 | 2219 | 0.245329 | -0.56 | 7.6e-06 | Click! |
| Zbtb18 | chr1_177444528_177444714 | 28 | 0.960270 | -0.56 | 9.8e-06 | Click! |
Showing 1 to 5 of 5 entries
Top target CREs of the motif:
| Cis Regulatory Element (CRE) | Target Score | Top associated gene | Gene Info | Distance of CRE to TSS | CRE/Gene association probability |
|---|---|---|---|---|---|
| chr8_25343429_25343737 | 55.18 |
5430421F17Rik |
RIKEN cDNA 5430421F17 gene |
37313 |
0.12 |
| chr5_134895375_134895572 | 54.80 |
Tmem270 |
transmembrane protein 270 |
11260 |
0.09 |
| chr19_56177181_56177795 | 51.63 |
Gm31912 |
predicted gene, 31912 |
71178 |
0.1 |
| chr2_174347204_174348264 | 50.76 |
Gm20721 |
predicted gene, 20721 |
1022 |
0.44 |
| chr4_139179928_139180623 | 48.99 |
Gm16287 |
predicted gene 16287 |
380 |
0.82 |
| chr5_137349031_137350198 | 45.22 |
Ephb4 |
Eph receptor B4 |
495 |
0.62 |
| chr17_25083410_25083921 | 42.90 |
Tmem204 |
transmembrane protein 204 |
74 |
0.95 |
| chr6_72248461_72248628 | 42.29 |
Atoh8 |
atonal bHLH transcription factor 8 |
12967 |
0.15 |
| chr3_152549002_152549525 | 41.40 |
Ak5 |
adenylate kinase 5 |
22511 |
0.2 |
| chr14_54443728_54443932 | 40.77 |
5430430K15Rik |
RIKEN cDNA 5430430K15 gene |
2488 |
0.12 |
Histogram of CRE-TSS distances for CREs targeted by :
Rank distribution of CRE target scores:
Distribution of target CREs across different genomic regions:
Network of associatons between targets according to the STRING database.
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 68.5 | GO:0007266 | Rho protein signal transduction(GO:0007266) |
| 3.4 | 60.9 | GO:0051497 | negative regulation of stress fiber assembly(GO:0051497) |
| 2.9 | 60.0 | GO:0001945 | lymph vessel development(GO:0001945) |
| 1.5 | 59.8 | GO:0007044 | cell-substrate junction assembly(GO:0007044) |
| 8.7 | 52.3 | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269) |
| 0.0 | 39.8 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 7.7 | 38.6 | GO:0060689 | cell differentiation involved in salivary gland development(GO:0060689) |
| 9.0 | 36.2 | GO:2000523 | regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) |
| 8.9 | 35.4 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 1.4 | 34.0 | GO:0006270 | DNA replication initiation(GO:0006270) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 496.4 | GO:0070062 | extracellular exosome(GO:0070062) |
| 1.0 | 266.6 | GO:0005925 | focal adhesion(GO:0005925) cell-substrate junction(GO:0030055) |
| 0.7 | 207.5 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.2 | 206.5 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.3 | 197.5 | GO:0005615 | extracellular space(GO:0005615) |
| 0.7 | 121.7 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 1.8 | 107.0 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 1.8 | 106.7 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.4 | 104.6 | GO:0005667 | transcription factor complex(GO:0005667) |
| 1.2 | 90.0 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 118.9 | GO:0005198 | structural molecule activity(GO:0005198) |
| 1.0 | 91.8 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.5 | 85.6 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 1.5 | 81.9 | GO:0005518 | collagen binding(GO:0005518) |
| 1.0 | 70.3 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 5.8 | 70.2 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.3 | 69.6 | GO:0003682 | chromatin binding(GO:0003682) |
| 1.0 | 68.9 | GO:0005178 | integrin binding(GO:0005178) |
| 0.6 | 62.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.4 | 50.8 | GO:0061659 | ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 174.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 3.5 | 148.6 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.5 | 120.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.6 | 119.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.7 | 97.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.9 | 83.2 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 2.1 | 65.7 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 1.0 | 61.1 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 1.9 | 59.7 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 2.0 | 53.0 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 162.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.9 | 96.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.2 | 86.5 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 2.4 | 63.0 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 4.4 | 61.2 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 1.1 | 60.7 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 3.3 | 55.5 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.7 | 51.0 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 1.2 | 50.4 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.2 | 46.3 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |